简 介

周搏航，男，中共党员，助理研究员；

2021/08--至今 中国科学院陕西省生物农业研究所，助理研究员

2016/08/28--2021/06/27西北农林科技大学，化学与药学院，化学生物学专业，获博士学位，读博期间自2019/09/01--2021/03/01由国家留学基金委资助前往加拿大女王大学（Queen’s University）进行联合培养；

2014/09/01--2021/08/01，西北农林科技大学，化学与药学院，化学生物学专业硕士，转为提前攻博生；

2010/09/01--2014/6/28 西安建筑科技大学华清学院，应用化学专业，获学士学位。

研究方向

小分子药物设计，天然产物提取，仿生合成

所获荣誉

2021年优秀博士论文

科研成果

论文：

1. Bohang Zhou, Hui Li, Zhiming Cui, Ding Li, Huiling Geng*,Jinming Gao*, Le Zhou*. Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase. European Journal of Medicinal Chemistry, 2020, 200, 112415.

2.Bohang Zhou # , Bingyu Zhang # , Xingqiang Li, Xiuxiu Liu, Hui Li,Ding Li, Zhiming Cui, Huiling Geng*, Le Zhou*. New 2-aryl-9-methyl-β-carbolinium salts as potential acetylcholinesterase inhibitor agents: synthesis, nioactivity and structure–activity relationship. Scientific Reports, 2018, 8, 1559.

3.Zhiming Cui # , Bohang Zhou # , Chao Fu, Liu Chen, Juan Fu, Fangjun Cao, Xinjuan Yang*, Le Zhou*. Simple analogues of quaternary benzo[c]phenanthridine alkaloids: discovery of a novel antifungal 2‐ phenylphthalazin-2-ium scaffold with excellent Potency against Phytopathogenic Fungi. Journal of Agricultural and Food Chemistry, 2020, 68, 15418‒15427.

4.Zhu Lifei # , Zhou Bohang # , Zhang Bingyu, Xu Mingxuan, Geng Huiling*, Zhou Le*. New 2-aryl-7,8-dimethoxy-3,4-dihydroisoquinolin-2-ium salts as potential antifungal agents: synthesis, bioactivity and structure-activity relationships. Scientific reports, 2017, 7(1), 7537.

5.Zhaofeng Gao # , Bohang Zhou # , Jieyu Zhao, Fangjun Cao, Le Zhou* and Huiling Geng*. Further study on chemical constituents of Parnassia wightiana Wall: four new dihydro-β-agarofuran sesquiterpene polyesters. International Journal of Molecular Sciences, 2015, 16, 9119‒9133.

6.Fangjun Cao, Mingxuan Xu, Bohang Zhou, Yisi Du, Junhu Yao*, Le Zhou*. Effects of 2-aryl-1-cyano-1,2,3,4-tetrohydroisoquinolines on apoptosis induction mechanism in NB4 and MKN-45 cells. Toxicology in Vitro, 2019, 54, 295‒303.

7.Fangjun Cao # , Li-Fei Zhu # , Qian Kuang, Xingqiang Li, Bohang Zhou, Xinjuan Yang*, Le Zhou*. Cytotoxic activity, apoptosis induction and structure–activity relationship of 8-OR-2-aryl-3,4-dihydroisoquinolin-2-ium salts as promising anticancer agents. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 55‒60.

8.Huiling Geng, Xinchi Yu, Ailin Lu, Haoqiang Cao, Bohang Zhou, Le Zhou*, Zhong Zhao*. Extraction, chemical composition, and antifungal activity of essential oil of bitter almond. International Journal of Molecular Sciences, 2016, 17(9), 1421/1‒1421/14.

专利：

1.周乐，周搏航，张冰玉，崔志明，候哲，耿会玲. 咔啉类化合物及其合成方法与抗乙酰胆碱酯酶活性，ZL 201611051173.1，2019.11.19.

2.周乐，童宗博, 周搏航, 李纬博, 杨新娟, 耿会玲. 秃疮花提取物及其提取方法与应用, ZL 201610935462.1,2019.03.19.

3.周乐，侯哲，周搏航, 朱丽飞, 杨新娟.β-咔啉类化合物及其合成方法、以及含有该化合物的药物及应用, ZL 201510966178.6,2018.03.06.

4.周乐，孙马蔷, 赵婕妤, 周搏航, 杨新娟, 耿会玲, 苗芳. α,β-不饱和酮化合物及其合成方法、以及含有该化合物的药物及应用, ZL201610047752.2,2019.03.01.